Elastomeric Artificial Extracellular Matrix for Intimately Bio-integrated Soft Bioelectronics
Despite advanced research in bio-integrated electronics, the substrates of these systems still limited to fully integrated into the biological system for their developed applications (e.g., on-skin, cardiac, and neural lamination) and cause inflammation and foreign body responses. Current wearable electronics rely on impenetrable, non-porous platforms that obstruct the natural diffusive and convective fluid flow and gas transfer. Consequently, the distinct interface between flexible electronics and soft biological tissue contributes to the delamination of the device and sensor inaccuracies. Furthermore, the micro spatial mechanical mismatch at the interface continuously evokes shear stress and thus further exacerbates biomedical complications. To solve critical challenges in current soft bioelectronics, we develop an elastomeric artificial extracellular matrix (ECM) enabling fully breathable, an open-mesh structural design with comparable mechanics to the biological with great cytocompatibility. The synthetic ECM-like elastomer substrates are readily applicable to the full range of soft bioelectronics for improved tissue integration and enabling long-term health monitoring for wearable and implantable devices for health monitoring.